Revised model for cell cycle regulation by iron: differential roles between transferrin and ferritin.

ABSTRACT: Iron is essential for neoplasms including natural killer (NK) cell lymphoma, and mainly supplemented by transferrin and stored by ferritin. Although accumulating studies had demonstrated that iron chelation arrests cell cycle progression at G1 phase, our previous studies showed the induction of DNA double strand break at S phase cell cycle without G1 arrest by selective inhibition of cellular transferrin uptake, indicating that the existence of some undiscovered differences in the roles of the two major iron sources for cell cycle regulation. In this study, we identified a novel cell cycle regulation of transferrin binding iron in NK cell lymphoma. Blocking transferrin uptake induced S phase arrest owing to the dysfunction of nascent DNA synthesis. Moreover, canonical G1 arrest was observe

SUBMITTER: Yanagiya R 

PROVIDER: S-EPMC12210300 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature