Core histone families of mollusca: systematic identification, evolutionary insights, and functional analysis.

ABSTRACT:

Background

Histones are the basic packaging units of eukaryotic DNA and are essential for the dynamics of chromatin and the regulation of epigenetics. Canonical histones and their variants exhibit important functional differences in biological processes. However, little is known about the role of histone family members in molluscs, which are known for their ecological and morphological diversity.

Results

Core histone families of 28 molluscan species (12 bivalves, 8 gastropods, 6 cephalopods, 1 scaphopod and 1 polyplacophora) were systematically identified. The evolutionary conservation and lineage-specific innovations were discovered using phylogenomic and transcriptomic analyses. Cephalopods showed a striking expansion of canonical histone genes with brain-enriched expressi

SUBMITTER: Guan Y 

PROVIDER: S-EPMC12210499 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature