Efficacy of vaccination therapy in newly diagnosed and recurrent glioblastoma patients: a meta-analysis.

ABSTRACT:

Background

Glioblastoma (GB) is the most common and fatal primary central nervous system malignancy in adults. Various immunotherapies, including vaccination, are under investigation for their potential to extend survival in GB patients. Vaccination therapy has shown variable but promising outcomes across studies. This meta-analysis aims to evaluate the efficacy of available vaccines for newly diagnosed and recurrent GB.

Methods

We conducted a systematic search in PubMed, Scopus, and Web of Science to identify randomized or non-randomized double-arm studies involving adult GB patients treated with vaccines. Overall survival (OS) and progression-free survival (PFS) were the primary outcomes, with effect sizes represented as hazard ratios (HR) and calculated using a random-eff

SUBMITTER: Karavolias I 

PROVIDER: S-EPMC12210592 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature