Analysis of NUDIX enzymes across fungi reveals previously unrecognized diversity.

ABSTRACT:

Background

The NUDIX superfamily encompasses highly diverse enzymes involved in a plethora of biological functions such as mRNA metabolism, DNA repair, and lipid peroxidation. These hydrolases are found in all domains of life and show surprising versatility in terms of the substrates that they process. The knowledge about the diversity of fungal NUDIX proteins is fragmentary, being largely limited to a small number of characterized enzymes from yeasts. To address this knowledge gap systematically, we performed a detailed analysis of the NUDIX hydrolases across 183 fungal proteomes.

Results

Members of six of the known NUDIX families were present in fungi being particularly abundant in Glomeromycota. Phylogenetic analysis and sequence clustering grouped fungal NUDIX enzymes in

SUBMITTER: Pasterny Z 

PROVIDER: S-EPMC12210691 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature