Targeting neutrophil-driven inflammation in adult-onset still's disease: molecular insights from gene expression profiles.

ABSTRACT:

Background

The rarity and heterogeneity of adult-onset Still's disease (AOSD) pose significant challenges in understanding its precise pathogenic mechanisms, developing effective treatment options, and establishing therapeutic strategies. A comprehensive analysis of gene expression profiles could help to bridge the knowledge gaps in those areas.

Methods

A blood transcriptomic dataset comprising 31 patients with AOSD and 22 healthy controls was fetched. Cellular and molecular features were identified by analyzing differentially expressed genes (DEGs) and functional enrichment. Optimal molecular targets for neutrophil activation were identified using kernel-based diffusion scoring techniques.

Results

Blood molecular signatures indicate that neutrophil degranulation is t

SUBMITTER: Baek IW 

PROVIDER: S-EPMC12210742 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature