Genetic mechanism of β-alanine metabolic pathway affecting colorectal cancer prognosis.

ABSTRACT:

Background

Colorectal cancer (CRC) is a common cause of cancer-related mortality and is mainly influenced by metabolic dysfunction. The β-alanine metabolic pathway plays an important role in altering the aggressiveness and metabolic characteristics of the cancer cells. This study aimed to investigate the genetic role of the β-alanine metabolic pathway in CRC patient survival.

Methods

Using a Cox regression model, we assessed the impact of 27 single-nucleotide polymorphisms (SNPs) from 31 genes in the β-alanine metabolic pathway on overall survival (OS) and progression-free survival (PFS) in 287 patients with CRC. Additional methods, including differential expression analysis, expression quantitative trait loci analysis, dual-luciferase reporter assay, and cell phenotype assa

SUBMITTER: Zhao T 

PROVIDER: S-EPMC12210834 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature