High genetic diversity of HIV-1 pol region and molecular transmission networks among people living with HIV-1 in Haikou, South China, 2005-2022.

ABSTRACT:

Background

Hainan is experiencing a continuous increase in newly diagnosed HIV-1 infections, highlighting the need for a comprehensive understanding of local transmission dynamics. This study aims to elucidate the genetic diversity and potential HIV-1 molecular transmission networks among people living with HIV-1 in Hainan, China.

Methods

We used the HIV-TRACE to infer the transmission dynamics of HIV-1 at a 1.5% gene distance threshold. The role of HIV-1 diversity in transmission networks was assessed through node influence measurement and centrality analysis.

Results

A total of 986 pol sequences were included, with CRF07_BC (43.71%) and CRF01_AE (37.12%) emerging as the predominant subtypes. Of these, 586 (59.43%) were clustered into the transmission networks, formi

SUBMITTER: Yu D 

PROVIDER: S-EPMC12210868 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature