Susceptibility toward cefiderocol and sulbactam-durlobactam in extensively drug-resistant <i>Acinetobacter baumannii</i> detected from ICU admission screening in Hanoi, Vietnam, 2023.

ABSTRACT: Infections due to carbapenem-resistant Acinetobacter baumannii (CRAB) pose significant clinical challenges due to limited treatment options. In this study, we investigated the molecular epidemiology, resistance profiles, and genomic characteristics of CRAB isolates from intensive care unit (ICU) admission screenings in Vietnam, focusing on susceptibility to the novel agents cefiderocol and sulbactam-durlobactam. Between 1 July and 31 October 2023, extended antibiotic susceptibility testing (AST) and whole-genome sequencing were performed on CRAB isolates obtained through ICU admission and weekly screenings at the 108 Military Central Hospital in Hanoi. CRAB colonization was detected in 31 of 691 ICU patients (4.5%), with 30 isolates classified as multidrug-resistant/extensively drug

SUBMITTER: Boutin S 

PROVIDER: S-EPMC12210873 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature