Exploring virulence and stress response in <i>Entamoeba histolytica</i>: insights from clinical strains.

ABSTRACT: Amebiasis, caused by the protozoan Entamoeba histolytica, is a significant parasitic infection affecting millions of people worldwide, particularly in developing regions. Elucidating the mechanisms by which this parasite invades host tissues and circumvents immune defenses is essential for advancing therapeutic strategies. Key virulence factors such as Gal/GalNAc lectin, amebapore, and proteases enable the parasite to adhere to, invade, and destroy host tissues. This study aimed to identify novel virulence-related genes in clinical E. histolytica strains by analyzing their gene expression profiles. We collected clinical isolates from asymptomatic individuals and patients with amoebic liver abscesses to perform RNA sequencing and compare their gene expression profiles. The ana

SUBMITTER: Yanagawa Y 

PROVIDER: S-EPMC12210921 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature