Evaluation of the role of <i>whiB6</i> and <i>kdpDE</i> in the dominant multidrug-resistant clone <i>Mycobacterium tuberculosis</i> B0/W148.

ABSTRACT: Multidrug-resistant (MDR) strains of Mycobacterium tuberculosis represent an obstacle to eradicating tuberculosis (TB) due to the low treatment success rate of MDR TB. Among them, the MDR B0/W148 clone has recently evolved from the M. tuberculosis Beijing lineage 2 and is widely disseminated in Russia and Europe. To get more insights into the genetic factors underlying the evolutionary success of the MDR M. tuberculosis B0/W148 clone in addition to environmental and patient-related features, we focused on two mutations specific to this clone that are found in the transcriptional regulators WhiB6 and KdpDE and investigated in a H37Rv strain background the transcriptional profile associated with these mutations and their impact on the in vitro and in vivo g

SUBMITTER: Bonnet I 

PROVIDER: S-EPMC12210973 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature