Infections caused by clonal spread of metallo-beta-lactamase-producing <i>Enterobacter cloacae</i> complex isolates at a southern Taiwan hospital.

ABSTRACT: Carbapenem-resistant Enterobacter cloacae complex (ECC) has become a clinically important pathogen with increased incidence worldwide in recent years. In Taiwan, IMP-8 accounted for most carbapenemase produced by ECC in earlier studies. Clinical ECC isolates resistant to ertapenem, imipenem, and meropenem at the study hospital between 2014 and 2022 were collected at a medical center in southern Taiwan. The isolates were subjected to multilocus sequence typing, species identification by hsp60 sequencing, polymerase chain reaction detection of beta-lactamase genes, antimicrobial susceptibility tests, and whole genome sequencing analysis. Fifty-four ECC isolates causing infections were included. Bloodstream (20 episodes, 37.0%) and lower respiratory tract infections (14, 25.9%)

SUBMITTER: Cia C-T 

PROVIDER: S-EPMC12210983 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature