Clinical outcomes of phenotype-guided treatment in group D carbapenemase-producing <i>Enterobacterales</i> bacteremia.

ABSTRACT: International guidance recommends ceftazidime-avibactam for OXA-48-type carbapenemase-producing Enterobacterales (OXA-48-CPE) infections. However, OXA-48-CPE lacking extended spectrum and AmpC β-lactamases may remain susceptible to third-generation cephalosporins (3GC), potentially allowing treatment without avibactam. OXA-23 also has variable hydrolytic activity against 3GC. This study reviewed the outcomes of OXA-CPE bloodstream infections treated based on phenotypic susceptibility testing. A retrospective review of OXA-48-CPE and OXA-23-CPE bloodstream infections was conducted from February 2022 to July 2024. Data on antimicrobial susceptibility, patient background, infection source, treatments, and outcomes were analyzed. Whole-genome sequencing (WGS) determined the presence of

SUBMITTER: Ngiam JN 

PROVIDER: S-EPMC12211033 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature