Cycloserine resistance among drug-resistant tuberculosis cases in Taiwan.

ABSTRACT: Cycloserine (CS) is a widely used drug for drug-resistant tuberculosis (DR-TB) treatment. The World Health Organization (WHO) recently suggested a critical concentration (CC) for CS using the MGIT 960 system (MGIT). To strengthen our DR-TB management program, we performed CS resistance analyses to provide comprehensive drug susceptibility testing (DST). This retrospective study included Mycobacterium tuberculosis complex (MTBC) isolates obtained from 114 rifampin-resistant (RR) and multidrug-resistant (MDR) TB cases. We compared the results of phenotypic DST (pDST) and genotypic DST (gDST) and evaluated the minimum inhibitory concentration (MIC) using both MGIT and the Sensititre MYCOTB MIC Plate (Sensititre). Sanger sequencing and whole-genome sequencing were conducted to analyze t

SUBMITTER: Wu S-H 

PROVIDER: S-EPMC12211041 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature