Genotypic characterization of extended-spectrum beta-lactamase-producing <i>E. coli</i> from dogs in northern Germany.

ABSTRACT: Antimicrobial resistance (AMR) is a growing concern in veterinary and public health, with extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli playing a significant role. This study examined 1,000 healthy and sick dogs from a veterinary clinic in northern Germany and identified 85 ESBL-producing E. coli. Whole-genome sequencing of these isolates revealed seven phylogroups. A (38.8%) and B1 (32.9%) were the most common. Multilocus sequence typing identified 42 sequence types (STs), with the globally occurring lineages ST744 and ST10 being predominant. Single nucleotide polymorphism analysis showed the clonal circulation of ST744 among dogs in shared environments, such as households or breeders, whereas ST10 isolates displayed greater genetic diversity. ST131, a p

SUBMITTER: Werhahn Beining M 

PROVIDER: S-EPMC12211048 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature