Poor surgical outcomes following Paenibacillus infant infectious hydrocephalus.

ABSTRACT:

Objective

The authors previously identified Paenibacillus species in the CSF of 44% of infants presenting for neurosurgical evaluation with findings consistent with postinfectious hydrocephalus (PIH) in Eastern Uganda. Here, they sought to compare outcomes among hydrocephalic infants with and without Paenibacillus detection at the time of hydrocephalus surgery.

Methods

In a prospective observational study of 189 infants with PIH who underwent a CSF diversion prior to 90 days of age, 78 had a positive CSF polymerase chain reaction result for Paenibacillus species (PP), and 111 had a negative result (PN). The primary outcome was diversion failure-free survival, defined as being alive without diversion failure at last patient contact. Secondary outcomes included overall surviva

SUBMITTER: Ericson JE 

PROVIDER: S-EPMC12211056 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature