Nebulization with differently sized 2% lidocaine atomized particles in awake tracheal intubation by video laryngoscopy: a proof-of-concept randomized trial.

ABSTRACT:

Background

Optimization of the individual topicalization technique during awake tracheal intubation (ATI) is critical, but how to accomplish this is still unknown. We hypothesized that there would be a difference between nebulization with different sizes of 2% lidocaine atomized particles in ATI by video laryngoscopy.

Methods

A total of 230 patients scheduled for ATI were recruited from September 2024 through January 2025. Forty-six participants were excluded, and 184 participants were randomly assigned to 4 treatment groups according to the size of the atomized particles of 2% lidocaine: A3 (3-4 μm), A6 (6-7 μm), A9 (9-10 μm), or A11 (11-12 μm).

Results

There were statistically significant differences among the four groups. Post hoc analysis using Dunnett test showed

SUBMITTER: Li C 

PROVIDER: S-EPMC12211172 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature