TRIM24 regulates chromatin remodeling and calcium dynamics in cardiomyocytes.

ABSTRACT:

Background

Cardiomyocyte proteostasis and calcium homeostasis are critical for maintaining cardiac function, with their dysregulation contributing to cardiac hypertrophy and heart failure. The Tripartite Motif Protein 24 (TRIM24), a well-characterized chromatin reader and transcriptional regulator in cancer, has recently emerged as a potential player in cardiac biology. However, its precise role in cardiomyocytes remains unclear. Using molecular, structural and functional approaches, this study investigates the impact of TRIM24 on cardiomyocyte function and gene regulation.

Methods

To dissect the molecular and functional role of TRIM24, we conducted RNA-sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq) in neonatal rat ventricular cardiomyocytes (NR

SUBMITTER: Neu M 

PROVIDER: S-EPMC12211185 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature