Bioinformatics and systems biology to identify underlying common pathogenesis of diabetic kidney disease and stenosis of arteriovenous fistula.

ABSTRACT:

Background

Diabetic nephropathy is an important cause of end-stage renal disease. Arteriovenous fistula (AVF) stenosis is closely associated with hyperglycemia. However, studies exploring biomarkers linking these two diseases are lacking, which may provide insight into the mechanisms underlying Diabetic kidney disease (DKD) comorbid AVF stenosis.

Objective

This study investigated the common pathogenesis of DKD and AVF stenosis.

Methods

Biomarkers were screened by identifying key genes common between DKD and AVF stenosis through differential gene analysis. GO, KEGG and GSEA enrichment analysis of DEGs were performed by cluster profiler. Immuno-infiltration analysis was performed by CIBERSORT. The predictive value of HPGD to distinguish DKD comorbid AVF stenosis was det

SUBMITTER: Fu M 

PROVIDER: S-EPMC12211224 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature