VEGFA (rs1570360, rs699947, rs3025033, rs2146323, rs3024997) genotypes in patients with laryngeal squamous cell carcinoma.

ABSTRACT:

Background

Laryngeal squamous cell carcinoma (LSCC) is a common and aggressive head and neck malignancy with poor prognosis due to late diagnosis and limited biomarkers. Angiogenesis, driven by vascular endothelial growth factor A (VEGFA), plays a key role in tumor growth and metastasis. Single nucleotide variants (SNVs) in the VEGFA gene have been linked to various cancers, but their role in LSCC remains unclear.

Methods

In this study, we investigated the association between VEGFA (rs1570360, rs699947, rs3025033, rs2146323, rs3024997) SNV and LSCC susceptibility in a large cohort of 297 LSCC patients and 390 age- and sex-matched control subjects. The DNA samples were obtained from peripheral blood leukocytes, which were purified using the DNA salting-out technique. Real-tim

SUBMITTER: Pasvenskaite A 

PROVIDER: S-EPMC12211324 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature