Proteome-wide Mendelian randomization and colocalization analysis identify therapeutic targets for stroke.

ABSTRACT:

Background

Stroke is a leading cause of death and disability worldwide, yet its treatment still faces significant challenges. Mendelian randomization (MR) has been widely used to discover new biomarkers and therapeutic targets. This study aimed to identify therapeutic targets for stroke within the plasma proteome range using MR.

Methods

We conducted a two-sample MR study, evaluating the causal relationships between 2,940 plasma proteins from the UK Biobank-Proteome-wide Association Study (UKB-PPP) and stroke, with further validation in 4,907 plasma proteins from Iceland. Subsequently, drug target proteins were determined using Bayesian colocalization, Summary data-based Mendelian randomization (SMR), and protein-protein interaction (PPI) network construction to validate the

SUBMITTER: Zhao X 

PROVIDER: S-EPMC12211327 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature