Bioinformatics identification and validation of m6A/m1A/m5C/m7G/ac4 C-modified genes in oral squamous cell carcinoma.

ABSTRACT:

Background

RNA modifications, including m6A, m1A, m5C, m7G, and ac4C, may play a role in the occurrence and development of cancer, such as proliferation. However, the effects of RNA modification-related genes (RRGs) in the development of oral squamous cell carcinoma (OSCC) have not been fully elucidated. The present study aimed to evaluate the effects and mechanisms of RRGs on OSCC development progression.

Methods

RNA-seq transcriptome data, along with clinical and prognostic information, were extracted for 328 patients with OSCC from the TCGA database. A total of 49 RRGs were analyzed for differential expression. We then performed Lasso analysis, as well as univariate and multivariate Cox regression analyses, followed by Kaplan-Meier survival analysis to identify relevant p

SUBMITTER: Lu CH 

PROVIDER: S-EPMC12211329 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature