Brain-derived neurotrophic factor and cytokines as predictors of cognitive impairment in adolescent and young adult cancer patients receiving chemotherapy: a longitudinal study.

ABSTRACT:

Background

Inflammatory signaling is linked with cancer-related cognitive impairment (CRCI), potentially through modulation of brain-derived neurotrophic factor (BDNF) expression. Here, we evaluate associations between plasma cytokines and BDNF and their relationship with cognition in a longitudinal study of adolescent and young adult cancer patients (AYAC) receiving chemotherapy and non-cancer controls (NC) (Clinicaltrials.gov: NCT03476070).

Methods

Newly diagnosed AYAC (15-39 years old) and age-matched NC completed the Functional Assessment of Cancer Therapy-Cognitive Function questionnaire (FACT-Cog), the Cambridge Neuropsychological Test Automated Battery (CANTAB), and blood draws every 3-6 months up to 12 months (AYAC) or 6 months (NC) from baseline. Plasma levels of cy

SUBMITTER: Trudeau J 

PROVIDER: S-EPMC12211463 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature