The CRM1-dependent NES^257-266 motif in the matrix protein: another factor influencing Newcastle disease virus propagation and virulence.

ABSTRACT: As an important structural protein of Newcastle disease virus (NDV), the M protein plays a crucial role in the assembly and budding of the virus. In previous reports, we confirmed the existence of a classical nuclear export signal (NES) sequence on the M protein (i.e., amino acids 257 to 266), which plays an important role in the nuclear export of the protein. In this study, we found that the NES^257-266 motif is associated with the evolutionary history of NDV, and found that the NES-mediated nuclear export efficiency of M proteins varies among different genotypes. Further research on the LaSota-NES and JSD0812-NES variants showed that the NES both affects the nuclear-cytoplasmic trafficking efficiency of M protein and influences the formation of virus-like particles (VLPs). The

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12211488 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature