Hypoxia extends lifespan but does not alter telomere length or oxidative stress in a solitary bee (Megachile rotundata).

ABSTRACT: Stress can influence lifespan in both positive and negative ways, depending on exposure intensity and duration. However, mechanisms driving positive stress effects on lifespan remain poorly understood. Prolonged hypoxia extends the lifespan of overwintering prepupal Megachile rotundata. Here, we explored telomere length and reduced oxidative stress as potential mechanisms of this extended lifespan. We hypothesized high antioxidant capacity under hypoxia reduces oxidative damage and telomere loss. We exposed prepupae to 10%, 21% or 24% oxygen for up to 9 months and measured monthly survival, telomere length, antioxidant capacity and lipid peroxidation across treatment duration for prepupae and adults. After 9 months of exposure, survival was highest in hypoxia and lowest in hyperoxia. Telom

SUBMITTER: Szejner-Sigal A 

PROVIDER: S-EPMC12211587 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature