Immune response of intestinal micrornas to transport stress in hybrid yellow catfish (tachysurus fulvidraco♀ ×t. vachellii♂) : response strategy and potential biomarker.

ABSTRACT: Fish transportation, a routine operation in aquaculture, can induce immune responses in fish, potentially affecting their health. Nevertheless, the immune response mechanisms involved in microRNAs (miRNAs) under transport stress remain unclear. Therefore, we investigated the immune response strategy of miRNAs in intestines of hybrid yellow catfish under transport stress via physiological, biochemical and RNA-seq analysis. We found that transportation induced innate immune response of intestines characterized by significant increases in alkaline phosphatase, acid phosphatase, lysozyme, and complement 3 level. Meanwhile, 50 differentially expressed miRNAs were identified and comprehensive analysis of miRNA-mRNA sequencing showed their targets genes involved in 9 immune-related pathways. Nota

SUBMITTER: Zheng T 

PROVIDER: S-EPMC12211779 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature