Non-linear relationship between the hepatic steatosis index and glycemic progression: evidence from a large-scale retrospective cohort study in a Chinese population.

ABSTRACT:

Background

The hepatic steatosis index (HSI) is a validated tool for assessing hepatic steatosis. While previous investigations have explored the link between HSI and prediabetes and diabetes, the connection between HSI and glycemic progression is still being explored. This research seeks to clarify the association between HSI and glycemic progression risk among a Chinese demographic.

Methods

The research encompassed a group of 76,314 Chinese adults from the Rich Healthcare Group who were free of prediabetes at the outset. Cox proportional hazard models were utilized to investigate the connection between the HSI and glycemic progression. Additionally, cubic spline function and smooth curve fitting in the Cox regression framework were applied to identify potential non-linear

SUBMITTER: Cao C 

PROVIDER: S-EPMC12211869 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature