Metformin-improved cognitive impairment in patients with schizophrenia is correlated with activation of tricarboxylic acid cycle and restored functional connectivity of hippocampus.

ABSTRACT:

Background

Cognitive impairment is a prominent feature that adversely affects the long-term prognosis of schizophrenia; yet effective clinical strategies for treatment remain limited. Disruptions in the tricarboxylic acid (TCA) cycle and functional brain abnormalities in the hippocampus may underlie cognitive deficits, although the intrinsic connections between these factors have yet to be fully elucidated. Notably, metformin, a biguanide anti-hyperglycemic agent, has been shown to improve several cognitive domains in patients with schizophrenia and may have the potential to regulate the TCA cycle. Previously, we found the cognitive improvement effect of adding metformin. In this study, we will further explore the relationship between cognitive improvement and TCA cycle metabolites

SUBMITTER: Cai J 

PROVIDER: S-EPMC12211882 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature