Peritoneal cavity-derived small extracellular vesicles from aged tumor-naive hosts promote ovarian cancer adhesion and invasion.

ABSTRACT:

Background

Epithelial ovarian cancer (OvCa) remains a leading cause of mortality among gynecological cancers. Metastasis to the peritoneum, characterized by tumor cell adhesion to and invasion of the mesothelial lining of the abdominal cavity, represents a critical early event in OvCa metastatic progression. The median age of diagnosis is 63 and there exists a strong correlation between advanced age, OvCa incidence and disease stage. Moreover, the aged peritoneal cavity represents a permissive niche for metastatic dissemination.

Methods

To investigate age-related factors that influence host-tumor communication in metastatic progression, the current study isolated small extracellular vesicles (sEVs) from the peritoneal lavage of healthy tumor-naïve young (3-6 month) and aged

SUBMITTER: Safavi-Sohi R 

PROVIDER: S-EPMC12211904 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature