Mesial-to-lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy.

ABSTRACT:

Objective

Mesial temporal lobe epilepsy is a common localization of drug-resistant epilepsy in adults. Patients often undergo intracranial electroencephalographic monitoring to confirm localization and determine candidacy for focal ablation or resection. Clinicians primarily base surgical decision-making on seizure onset patterns, with imaging abnormalities and information from interictal epileptiform discharge (spikes) used as ancillary data. How the morphology and timing of spikes within multielectrode sequences may inform surgical planning is unknown, in part due to the lack of measurement methods for large datasets. We hypothesized that patients with mesial temporal lobe epilepsy have a distinct mesial-to-lateral spike gradient that differentiates them from other epilepsy local

SUBMITTER: Aguila CA 

PROVIDER: S-EPMC12212069 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature