Regeneration alters open chromatin and <i>cis</i>-regulatory landscape of erythroid precursors.

ABSTRACT: Stress erythropoiesis elevates the rate of red blood cell (RBC) production as a physiological response to stressors such as anemia or hypoxia. In acute anemia, RBC progenitors and precursors temporarily rewire their transcriptome, up- and downregulating hundreds of genes to accelerate the production of mature RBCs. Effective regeneration requires communication between critical cytokine signals (e.g., BMP4) and cis-regulatory elements on chromatin which coordinate transcriptional changes. To identify cis-regulatory changes that underlie anemia-specific gene expression and cellular responses, we analyzed chromatin accessibility in populations of cells enriched for red blood cell precursors isolated from mice at a range of time points after anemia induction. Early in the anemia

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12212076 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature