Developmental transcriptomics in <i>Pristionchus</i> reveals the environmental responsiveness of a plasticity gene-regulatory network.

ABSTRACT: Developmental plasticity enables the production of alternative phenotypes in response to different environmental conditions. Although significant advances in understanding the ecological and evolutionary implications of plasticity have been made, understanding its genetic basis has lagged. However, a decade of genetic screens in the model nematode Pristionchus pacificus has culminated in the identification of more than 30 genes that affect mouth form. We also recently reported the critical window of environmental sensitivity and therefore have clear expectations for when differential gene expression should matter. Here, we collated existing data into a gene-regulatory network (GRN) and performed developmental transcriptomics across different environmental conditions, genetic backgro

SUBMITTER: Reich S 

PROVIDER: S-EPMC12212086 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature