Subclinical ketosis in postpartum dairy cows alters the adipose tissue immunological profile in a depot-specific manner.

ABSTRACT:

Introduction

Subclinical ketosis (SCK) is a common metabolic disorder linked to adipose tissue (AT) dysfunction in periparturient dairy cows. While subcutaneous AT (SAT) and visceral AT (VAT) differ in structure, cellularity, and function, depot-specific responses to ketosis remain poorly understood. This study aimed to determine the transcriptional differences of flank SAT and omental VAT in early lactation dairy cows in response to SCK.

Methods

Multiparous Holstein dairy cows within the first 10 days postpartum were screened for SCK. Subclinical ketosis was defined as blood β-hydroxybutyrate (BHB) concentrations between 1.4 and 2.6 mmol/L, while control, non-ketotic animals (NK) had BHB equal to or lower than 0.8 mmol/L. Adipose tissue biopsies were obtained from flank SAT

SUBMITTER: Michelotti TC 

PROVIDER: S-EPMC12212114 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature