Histological Assessment of Foveal Mechanical Instability and Potential Implications for Macular Diseases.

ABSTRACT:

Purpose

To assess areas of mechanical instability in the fovea based on a review of artifactual separations of histological sections.

Methods

A collection of annotated high-resolution retinal histological sections of aged donors was assessed for tissue disruptions in the fovea. Sections belong to Project MACULA (https://projectmacula.org).

Results

Sections (mean length, 7467 ± 491 µm) through 75 foveas were analyzed (61% [46/75] from females; mean age at death, 81.3 years). Of these, 68% (51/75) were normal-aged, and 32% (24/75) showed early non-neovascular AMD. Separation of the neurosensory retina from the RPE occurred in 96% of sections (72/75). A break between the photoreceptor inner and outer segments was observed in 57% of cases (41/72), and bacillary layer deta

SUBMITTER: Martins Melo I 

PROVIDER: S-EPMC12212445 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature