VISTA: A Tool for Fast Taxonomic Assignment of Viral Genome Sequences.

ABSTRACT: The rapid expansion of the number of viral genome sequences in public databases necessitates a scalable, universal, and automated preliminary taxonomic framework for comprehensive virus studies. Here, we introduce Virus Sequence-based Taxonomy Assignment (VISTA), a computational tool that employs a novel pairwise sequence comparison system and an automatic demarcation threshold identification framework for virus taxonomy. Leveraging physio-chemical property sequences, k-mer profiles, and machine learning techniques, VISTA constructs a robust distance-based framework for taxonomic assignment. Functionally similar to Pairwise Sequence Comparison (PASC), a widely used virus assignment tool based on pairwise sequence comparison, VISTA demonstrates superior performance by providing significantl

SUBMITTER: Zhang 张韬 T 

PROVIDER: S-EPMC12212643 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature