Pharmacological assessment of <i>Coffea arabica</i> compounds as potential therapeutics for cervical cancer.

ABSTRACT:

Motivation

Cervical cancer remains a leading cause of gynecological mortality, with existing treatments often limited by resistance and suboptimal efficacy. While Coffea arabica is rich in phytochemicals with reported anticancer properties, their relevance to cervical cancer-specific molecular targets remains underexplored. Here, we integrated transcriptomic profiling, cheminformatics, and survival modeling to evaluate the therapeutic potential of C. arabica compounds in cervical cancer.

Results

From 158 bioactive compounds with favorable pharmacokinetic and drug-likeness properties, we predicted gene targets and intersected them with 1779 differentially expressed genes identified from bulk RNA-sequencing of 304 cervical cancer tumors and 47 normal cervical tis

SUBMITTER: Omoboyede V 

PROVIDER: S-EPMC12212767 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature