Causal relationship between inflammatory factors and inflammatory bowel disease: A bidirectional Mendelian randomization study combined with meta-analysis.

ABSTRACT: Due to the limitations of traditional observational studies, investigating the association between inflammatory factors and inflammatory bowel disease (IBD) remains challenging. In this study, we employed Mendelian randomization (MR) combined with meta-analysis to assess the causal relationship between 91 inflammatory factors and IBD. We selected genome-wide association study (GWAS) data for inflammatory factors and IBD from GWAS databases and conducted 2-sample MR analyses using the inverse-variance weighted (IVW) method, MR-Egger regression, and weighted median estimator. The MR analyses were performed for 91 inflammatory factors with IBD outcome data from 2 different databases. Subsequently, a meta-analysis of the main IVW results was conducted, followed by multiple corrections of the m

SUBMITTER: Ji X 

PROVIDER: S-EPMC12212840 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature