Investigating Overlapping Genetic Factors and Novel Causal Genes in Autoimmune Diseases: A Transcriptome-Wide Association and Multiomics Study.

ABSTRACT: Background: Autoimmune diseases exhibit familial clustering and co-occurrence, suggesting the presence of shared genetic risk factors. However, the overlapping genetic factors across these diseases have yet to be fully elucidated. This study aimed to identify shared genetic factors across five autoimmune diseases: systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), ankylosing spondylitis (AS), Sjögren's syndrome (SS), and polymyalgia rheumatica (PMR). Methods: A blood tissue-based transcriptome-wide association study (TWAS) was conducted to identify candidate genes. Bayesian colocalization analysis was employed to pinpoint genetic variants shared across diseases. Multiomics summary data-based Mendelian randomization (SMR) was used to identify causal risk genes, whi

SUBMITTER: Fu L 

PROVIDER: S-EPMC12213038 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature