An integrated multifocal tDCS-EEG protocol for reducing cognitive and affective symptoms in mild cognitive impairment and early stages of dementia: a crossover double-blind randomized controlled trial.

ABSTRACT:

Background

Available evidence on effectiveness of non-pharmacological interventions for cognitive and affective symptoms in Mild Cognitive Impairment (MCI) and the early stages of dementia is encouraging but still limited. Multifocal high-definition brain stimulation could detain the potential of improving these symptoms by modulating the activity of a fronto-temporal network. Moreover, combined electrophysiological measures might contribute monitoring the underlying neurophysiological effects. In this study protocol an innovative and integrated intervention for patients with MCI and early-stage dementia will be proposed, also exploring the modulatory role of some specific variables such as education and cognitive reserve.

Method

Sixty patients with MCI and early-stage demen

SUBMITTER: Catalano L 

PROVIDER: S-EPMC12213475 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature