Genetic diversity of norovirus in Shenzhen Based on continuous surveillance from 2016 to 2022.

ABSTRACT:

Introduction

Norovirus is a key pathogen of acute gastroenteritis and poses a significant burden on both the economy and public health. This study focuses on continuous monitoring of norovirus in Shenzhen, China, from 2016 to 2022, aiming to analyze the epidemic characteristics and genetic diversity of norovirus in the context of global sequence data.

Methods

The study was based on data collected from local sentinel hospitals. It involved analyzing the demographic, spatial, and temporal distribution of norovirus infections. Phylogenetic analysis was conducted, and genotype dynamics were compared across geographic levels. Mutations affecting protein stability were evaluated, and recombination analysis was performed to identify critical breakpoints and fragments for norovirus.

SUBMITTER: Wang X 

PROVIDER: S-EPMC12213568 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature