Epigenetic mechanisms linking atherosclerosis to ischemic stroke: insights from DNA methylation and transcriptome integration.

ABSTRACT:

Background

Ischemic stroke (IS) is a major cause of mortality and disability, with atherosclerosis (AS) as a primary risk factor. DNA methylation plays a critical role in AS development, but its regulatory mechanisms remain unclear. This study aims to investigate the epigenetic regulatory mechanisms linking AS and IS by integrating DNA methylation and transcriptome data from public databases.

Methods

This study integrated DNA methylation (GSE46394) and transcriptome data (GSE111782 and GSE162955) from public databases to investigate the molecular mechanisms linking AS and IS. Differentially methylated CpG positions (DMPs) and differentially expressed genes (DEGs) were identified (p < 0.05). Subsequent gene annotation and enrichment analyses were performed to uncover potentia

SUBMITTER: Ding B 

PROVIDER: S-EPMC12213582 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature