Type VII secretion system gene mutations driving global mycobacterium tuberculosis transmission revealed by whole genomic sequence.

ABSTRACT: Pathogenic mycobacteria are able to transfer virulence factors across their complex cell wall using a type VII secretion system (T7SS)/early secreted antigenic target-6 of the kDa secretion system (ESX). Since the discovery of ESX loci during the Mycobacterium tuberculosis H37Rv genome project, extensive research in areas such as structural biology, cell biology, and evolutionary analysis has improved our understanding of the role of these systems. However, regulatory mechanisms for ESX in Mycobacterium tuberculosis remain elusive. Despite extensive research, the effects of ESX gene mutations on the dynamics of Mycobacterium tuberculosis transmission are not well understood. In this study, we investigated the role of ESX mutations in TB transmission, assessing their risk and characteristic

SUBMITTER: Yang JJ 

PROVIDER: S-EPMC12213627 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature