Anxiety-related gut microbiota alterations in Parkinson's disease: distinct associations compared to healthy individuals.

ABSTRACT:

Background and objectives

Anxiety affects 25-49% of Parkinson's disease (PD) patients, exacerbating non-motor symptoms and significantly reducing quality of life. Growing evidence suggests that gut microbiota plays a role in anxiety, but whether its impact differs between PD and non-PD populations remains unclear. This study explores the heterogeneity of gut microbiota-associated anxiety in PD and non-PD individuals.

Methods

Participants from the NeuroGenetics Research Consortium provided clinical data, including PD status, anxiety status, and stool samples analyzed via 16S rRNA sequencing. After excluding nine participants with missing anxiety data, 322 individuals were included (193 PD, 129 non-PD). We assessed α-diversity, β-diversity, taxonomic composition, and functiona

SUBMITTER: Lin SH 

PROVIDER: S-EPMC12213657 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature