<i>Acanthamoeba castellanii</i> as a model for unveiling <i>Campylobacter jejuni</i> host-pathogen dynamics.

ABSTRACT: The persistence of the major enteric pathogen Campylobacter jejuni in the natural environment, despite being microaerophilic, remains unsolved. Its survival in the natural atmospheric environment likely stems from several factors, including interactions with amoebae. C. jejuni transiently interacts with Acanthamoeba, and this is thought to provide protection against unfavorable atmospheric conditions and subsequently prime the bacteria for interactions with warm-blooded hosts. Acanthamoeba play vital roles in microbial ecosystems by preying on bacterial species, some of which are clinically important. We analyzed the whole transcriptome of A. castellanii infected with C. jejuni 11168H. Our findings provide evidence that infection of A. castellanii with

SUBMITTER: Nasher F 

PROVIDER: S-EPMC12213738 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature