<i>SIRT2</i>-dependent <i>CPT1A</i> deacetylation in macrophages inhibits periodontitis.

ABSTRACT:

Introduction

Periodontitis is intricately related to systemic disorders and exerts a negative impact on quality of life. Recent studies have suggested a potential association between periodontitis and fatty acid oxidation (FAO), a key metabolic process involved in energy production and cellular function. However, the molecular mechanisms underlying this relationship remain insufficiently understood. This study aims to explore the role of carnitine palmitoyltransferase 1A (CPT1A), a pivotal enzyme in fatty acid oxidation (FAO), in the pathogenesis of periodontitis.

Methods

The involvement of FAO in periodontitis was validated through bioinformatics analysis and quantitative real-time polymerase chain reaction (qRT-PCR). The anti-inflammatory effects of the CPT1A

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12213876 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature