Temporal dichotomy of neutrophil function in acute liver injury and repair.

ABSTRACT:

Background & aims

Acetaminophen (APAP)-induced acute liver injury (APAP-ALI) is the leading cause of acute liver failure-induced death, with host innate immune responses driving outcomes. Neutrophils are activated and increased in APAP-ALI and reported to contribute to liver damage. However, neutrophil dysfunction in patients with acute liver failure is associated with non-survival, and recent reports highlight their importance in hepatic repair. Neutrophil-targeted therapies for APAP-ALI are hampered by this controversy and a lack of time-dependent investigation.

Methods

Hepatic neutrophils were depleted at different times in a wild-type mouse model of APAP-ALI. Fpr1 ^-/- mice, with reduced neutrophil activation, were also used. The impact of neutrop

SUBMITTER: Cartwright JA 

PROVIDER: S-EPMC12213964 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature