In-vitro-cytotoxicity of cariostatic agents based on fluorides and lanthanide salts in L-929 fibroblasts.

ABSTRACT:

Objectives

Fluoride-based cariostatic agents are commonly used in dental products and are generally considered safe. However, ongoing discussions about potential adverse effects are driving research into alternative agents, such as lanthanide salts. This study aims to evaluate the cytotoxic effects of different cariostatic agents, including fluoride compounds (NaF, Na₂PO₃F, NH₄F) and lanthanide salts (Ce(NO₃)₃, CeCl₃, Sm(NO₃)₃, SmCl₃).

Materials and methods

Mouse fibroblasts (L-929) were cultured in Eagle's Minimum Essential Medium supplemented with 5% fetal bovine serum and 1% penicillin-streptomycin. Cell viability was assessed via MTT assay after 24 h of exposure to test com

SUBMITTER: Akamp T 

PROVIDER: S-EPMC12213984 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature