Dynamics of serum tumor markers may indicate the progression of interstitial lung disease in Sjogren's syndrome patients: new roles for old friends.

ABSTRACT: A retrospective case-control study was designed to identify the characteristics and predictors of primary Sjögren's syndrome (pSS)-associated progressive fibrosing interstitial lung disease (ILD). Patients who diagnosed pSS-ILD were enrolled from Shanghai Tongji Hospital between January 1, 2015, and September 30, 2023. Relevant clinical data, including medical history, laboratory test results, and imaging findings, were collected at baseline. Progressive pulmonary fibrosis (PPF) was defined as established standard during one year of follow-up. Multiple linear regression was used to assess the relationship between tumor markers and ILD activity status. Characteristics associated with progression were determined by COX regression analysis. Kaplan-Meier survival analysis was employed to evalu

SUBMITTER: Song J 

PROVIDER: S-EPMC12214032 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature