GFOD1 expression in clear cell renal cell carcinoma and its role in cancer cell proliferation, migration, and invasion.

ABSTRACT:

Background

The goal of this research was to examine the expression levels of Glucose-Fructose Oxidoreductase Domain Containing 1 (GFOD1) and to explore how it influences the proliferation, migration, and invasion of cancer cells in clear cell renal cell carcinoma (ccRCC, also known as KIRC).

Methods

The Cancer Genome Atlas (TCGA) database was used to compare GFOD1 expression levels across various tumors, as well as differences in GFOD1 expression between individual tumors and their adjacent tissues. The expression of GFOD1 in bladder cancer, KIRC, renal chromophobe cell carcinoma, renal papillary carcinoma, and prostate cancer was evaluated using qRT-PCR and immunohistochemistry. The prognostic value of GFOD1 in KIRC patients from the TCGA database was analyzed using the Kap

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12214071 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature