The mediating factors between systemic lupus erythematosus and prostate cancer risk: a two-step Mendelian randomization and transcriptome analysis.

ABSTRACT:

Background

Previous studies indicate an inverse association between systemic lupus erythematosus (SLE) and prostate cancer (PCa) risk. However, the underlying pathways remain unclear. Therefore, this study aims to elucidate the potential pathways through which SLE influences PCa and explore therapeutic targets.

Methods

First, we performed two-sample Mendelian randomization (MR) to confirm the causal relationship between SLE and PCa risk, followed by a two-step MR analysis to evaluate the mediation effects of immune cell characteristics and sex hormone levels. Next, comprehensive sensitivity analyses were conducted to ensure robustness, including heterogeneity testing, pleiotropy assessment, and leave-one-out validation. Then, we integrated transcriptomic data from SLE and PC

SUBMITTER: Zhong S 

PROVIDER: S-EPMC12214091 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature