Rhaponticin inhibits the proliferation, migration, and invasion of head and neck squamous cell carcinoma (HNSCC) cells through modulation of the IL6/STAT3 signaling pathway.

ABSTRACT:

Background

Rhaponticin, a bioactive compound derived from rhubarb, has been demonstrated anti-tumor effects in various types of cancer. However, its impact on HNSCC remains unexplored. This study aims to investigate the specific molecular mechanisms by which Rhaponticin inhibits the invasion and metastasis of HNSCC cells.

Method

The potential target genes that rhaponticin acts on in HNSCC were identified using online databases. The mechanisms by which rhaponticin influences the occurrence and progression of HNSCC were investigated through network pharmacology, molecular docking, bioinformatics analysis, and cellular experiments.

Result

Using network pharmacology, we identified 40 hub genes from the collected gene set. Subsequently, by analyzing The Cancer Genome Atlas

SUBMITTER: Wei H 

PROVIDER: S-EPMC12214110 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature